The Order of the Ursuline Sisters of Mary Immaculate (UMI), a religious congregation, took over the Holy Family Hospital in 1978. The Order was founded by Sister Brigida Morello in Piacenza, Italy, in 1649. Though it was the Congregation's original aim to educate young women who had no access to education, its mission expanded in India to include diverse forms of service - medical, social and pastoral.

They arrived in Kerala in 1934 to uplift weaker sections of society in the Malabar region and also ran dispensaries and visited patients at home. This was the UMI's foray into medical services. This new vision culminated in the setting up of the Congregation's first major hospital in India - Mariampur in Kanpur in Uttar Pradesh, in 1961.